August 20, 2011

Mimicking biological complexity, in a tiny particle

Sean C. -- very small particles made of polymers have potential, they could be the bare bones of basic structures, or even targeted drug delivery systems. as of now though they are limited, difficult to create and without much variety. a group of M.I.T. engineers have started to figure out how to overcome these disadvantages by changing the way that the polymer particles are made. it used to be that they had to use u.v. rays to solidify gel with drugs in them, it didn't have much precision, didn't work on many materiel's and the UV rays could possibly hurt cells. another way was filling molds with a almost fluid drug containing gel then to cool it until it reaches the right shape. The M.I.T. engineers overcame this with a mold that will shrink or expand based on the temperature. after they fill the molds with liquid gel with one type of cell or drug they wait for the gel to dry and then apply heat to the mold, causing it to shrink away the gel. this way they can add multiple layers to a creation. as of now they have been able to make cylinders and cube type shapes. eventually they hope to replicate entire organs even!
this would be pretty cool. i don't know how it would work but ti did say that they could have targeted delivery systems which is VERY important, it can let you use powerful destructive drugs with the precision, only hurting what it wants to. furthermore the ability to create organs would be extremely useful, it would speed up medicinal testing and maybe provide replacement organs for people with diseases. i wonder how many materials there able to do this with? how long will it take them to start using it actively? I'm not sure why multiple lairs are important but i think that tissue is composed of multiple layers so you wouldn't be able to create it without multiple layers. once again i had to chose a article were i cant really review well because i barley get the basics of the stuff there talking about, but come on those are the FUN ones.

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